Hiroyuki Nakashima Selected Research

Shwartzman Phenomenon (Shwartzman Reaction)

7/2019	Immune Mechanisms Underlying Susceptibility to Endotoxin Shock in Aged Hosts: Implication in Age-Augmented Generalized Shwartzman Reaction.
6/2009	Novel mechanism of C-reactive protein for enhancing mouse liver innate immunity.

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Hiroyuki Nakashima Research Topics

Disease

4	Neoplasms (Cancer) 07/2021 - 06/2004
4	Hepatitis 10/2019 - 12/2008
3	Bacterial Infections (Bacterial Infection) 10/2021 - 08/2013
3	Infections 10/2021 - 12/2004
2	Albuminuria 01/2022 - 12/2021
2	Diabetic Nephropathies (Diabetic Nephropathy) 01/2022 - 12/2021
2	Inflammation (Inflammations) 12/2021 - 04/2013
2	Neoplasm Metastasis (Metastasis) 07/2021 - 09/2003
2	Atherosclerosis 01/2021 - 01/2021
2	Shwartzman Phenomenon (Shwartzman Reaction) 07/2019 - 06/2009
2	Fatty Liver 01/2018 - 10/2016
2	Septic Shock (Toxic Shock Syndrome) 08/2013 - 06/2009
2	Brain Ischemia (Cerebral Ischemia) 01/2010 - 04/2002
1	Heat Stroke (Heatstroke) 05/2022
1	Obesity 01/2022
1	Aortic Dissection 01/2022
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2022
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 12/2021
1	Malaria 10/2021
1	Parasitemia 10/2021
1	Dyslipidemias (Dyslipidemia) 01/2021
1	Peritonitis 01/2021
1	Fibrosis (Cirrhosis) 11/2019
1	Liver Cirrhosis (Hepatic Cirrhosis) 11/2019
1	Acute Kidney Injury (Acute Renal Failure) 05/2019
1	Hematuria 05/2019
1	Lupus Nephritis 01/2018
1	Proteinuria 01/2018
1	Sepsis (Septicemia) 01/2017
1	Disease Progression 10/2016
1	Carcinogenesis 12/2015
1	Dermatitis 04/2013
1	Atopic Dermatitis (Atopic Eczema) 04/2013

Drug/Important Bio-Agent (IBA)

10	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2021 - 01/2005
7	alpha-galactosylceramideIBA 05/2019 - 06/2004
4	LipopolysaccharidesIBA 10/2021 - 06/2009
3	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2019 - 12/2008
3	Fas Ligand Protein (Fas Ligand)IBA 05/2019 - 10/2005
3	LigandsIBA 05/2019 - 11/2008
2	Interferon-gamma (Interferon, gamma)IBA 10/2021 - 07/2011
2	Apolipoproteins E (ApoE)IBA 01/2021 - 01/2021
2	C-Reactive ProteinIBA 01/2021 - 08/2013
2	Concanavalin AIBA 10/2019 - 12/2008
2	CytokinesIBA 10/2019 - 12/2008
2	CholesterolIBA 01/2018 - 01/2013
2	Messenger RNA (mRNA)IBA 01/2017 - 09/2004
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2010 - 11/2005
2	Interleukin-12 (IL 12)IBA 06/2009 - 09/2004
2	gadolinium chlorideIBA 12/2008 - 01/2005
1	Fatty Acid-Binding ProteinsIBA 05/2022
1	Hexosaminidases (Hexosaminidase)IBA 05/2022
1	Lipocalin-2IBA 05/2022
1	Carnitine (L-Carnitine)FDA LinkGeneric 01/2022
1	Mitochondrial DNA (mtDNA)IBA 01/2022
1	superoxide dismutase 2IBA 01/2022
1	CreatinineIBA 12/2021
1	INCB3344IBA 12/2021
1	Toll-Like Receptor 9IBA 12/2021
1	Luminescent ProteinsIBA 07/2021
1	Therapeutic UsesIBA 01/2021
1	oxidized low density lipoproteinIBA 01/2021
1	alirocumabIBA 01/2021
1	Proprotein Convertase 9IBA 01/2021
1	Scavenger Receptors (Scavenger Receptor)IBA 01/2021
1	disodium (R,R)- 5- (2- ((2- (3- chlorophenyl)- 2- hydroxyethyl)- amino)propyl)- 1,3- benzodioxole- 2,3- dicarboxylateIBA 01/2021
1	VLDL CholesterolIBA 01/2021
1	Lipoproteins (Lipoprotein)IBA 01/2021
1	LDL Lipoproteins (beta Lipoproteins)IBA 01/2021
1	VLDL LipoproteinsIBA 01/2021
1	LDL Receptors (LDL Receptor)IBA 01/2021
1	Choline (Choline Chloride)IBA 11/2019
1	ChitinasesIBA 11/2019
1	Methionine (L-Methionine)FDA Link 11/2019
1	Proteins (Proteins, Gene)FDA Link 11/2019
1	Carbon Tetrachloride (Tetrachloromethane)IBA 11/2019
1	Calcitriol Receptors (Calcitriol Receptor)IBA 10/2019
1	T-Cell Antigen Receptors (T-Cell Receptor)IBA 07/2019
1	PerforinIBA 05/2019
1	GlycosphingolipidsIBA 05/2019
1	Urea (Carbamide)FDA LinkGeneric 01/2018
1	NitrogenIBA 01/2018
1	chlorotriphenylsilane (CTPS)IBA 01/2017
1	Clodronic Acid (Clodronate)IBA 10/2016
1	Fibroblast Growth Factor 5IBA 10/2016
1	Liposomes (Liposome)IBA 10/2016
1	DNA (Deoxyribonucleic Acid)IBA 12/2015
1	EndotoxinsIBA 08/2013
1	Arachidonate 5-Lipoxygenase (5 Lipoxygenase)IBA 04/2013
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 04/2013
1	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 04/2013
1	Arachidonic Acid (Vitamin F)IBA 04/2013
1	alpha-Linolenic Acid (Linolenic Acid)IBA 04/2013
1	Triglycerides (Triacylglycerol)IBA 01/2013
1	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 07/2011
1	Macrophage Inflammatory Proteins (Macrophage Inflammatory Protein 1)IBA 07/2011
1	Interleukin-18 (Interleukin 18)IBA 07/2011
1	Interleukin-17 (Interleukin 17)IBA 07/2011

Therapy/Procedure

4	Therapeutics 01/2022 - 09/2003
3	Injections 10/2021 - 04/2002
1	Transplantation 01/2017